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On July 20, 2023, the United Kingdom issued the Cosmetic Products (Restriction of Chemical Substances) Regulations 2023 (No. 836 of 2023), to revise the requirements for the use of Methyl-N-methylanthranilate (CAS No. 85-91-6), HAA, and HAA (nano) (CAS No. 919803-06-8). This regulation applies to England, Wales, and Scotland.

Amendment to Annex 3 (comes into force on July 6, 2024).

Chemical Name/INN

Name of Common Ingredients Glossory

CAS number

EC number

Product type, Body parts

Maximum concentration in ready for use preparation

Other

Methyl-N-methylanthranilate

85-91-6

201-642-6

(a) Leave-on products

(b) Rinse-off products

0.1%

0.2%

For leave on products only: Not to be used in sunscreen products and products marketed for exposure to natural or artificial UV light.

For leave-on and rinse-off products: Do not use with nitrosating agents; Maximum nitrosamine content: 50μg/kg; Keep in nitrite-free containers.”

A cosmetic product that is placed on the market prior to July 6, 2024, can continue to be made available on the market until July 6, 2026.

Amendment to Annex 6 (comes into force on August 10, 2024).

Chemical Name/INN

Name of Common Ingredients Glossary

CAS number

EC number

Product type, Body parts

Maximum concentration in ready-for-use preparation

Other

1,1’-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone

Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine

919803-06-8

485-100-6

10%

In case of combined use of Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine and Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (nano), the sum shall not exceed 10%.

1,1’-(1,4-piperazinediyl)bis[1-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone

Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (nano)

919803-06-8

485-100-6

10%

Only nanomaterials having the following characteristics are allowed:

- Purity ≥ 97%,

- Median particle size D50 (50% of the number below this diameter): ≥ 50nm of number size distribution.

Not to be used in applications that may lead to exposure of the end user’s lungs by inhalation.

In case of combined use of Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine and Bis-(Diethylaminohydroxybenzoyl Benzoyl) Piperazine (nano), the sum shall not exceed 10%. ”

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United Kingdom Revised the Cosmetic Products (Restriction of Chemical Substances) Regulations 2023