SCCS Issued a Preliminary Opinion on the Inhalation Toxicity of the Fragrance Ingredient Acetylated Vetiver Oil in Sprayable Cosmetic Products

On March 5, 2024, the Scientific Committee on Consumer Safety (SCCS) of the European Union issued the preliminary opinion (SCCS/1663/24) on the inhalation toxicity of the fragrance ingredient Acetylated Vetiver Oil – AVO (CAS No 84082-84-8, EC No 282-031-1) in sprayable cosmetic products. The deadline for comments is set on 3 May 2024 .

The SCCS concludes the following:

In light of the data provided concerning inhalation toxicity, does the SCCS consider Acetylated Vetiver Oil (AVO) safe when used in sprayable cosmetic products with intended maximum concentrations (IMCs) of 0.9% (w/w) in fragrance pump sprays, 0.05% (w/w) in deodorant sprays and 0.1% (w/w) in hairsprays and body lotion sprays?

Having considered the data provided concerning inhalation toxicity and aggregate exposure, the SCCS considers Acetylated Vetiver Oil (AVO) (with 1% alpha11 tocopherol) safe when used at the intended maximum concentrations (IMCs) of 0.9%(w/w) in fragrance pump sprays, 0.05% (w/w) in deodorant sprays and 0.1% (w/w) in hairsprays and body lotion sprays. The findings of an in vitro study using Mucilair™ also support this conclusion.

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