SCCS Issued a Preliminary Opinion on Hydroxypropyl P-phenylenediamine and Its Dihydrochloride Salt (A165)

On November 7, 2023, the European Union Scientific Committee on Consumer Safety (SCCS) pulished the preliminary opinion(SCCS/1659/23) on Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (CAS/EC No. 73793-79-0/827-723-1 and 1928659-47-5/-). The deadline for comments was set for 8 January 2024.

The SCCS concludes the following:

1. In light of the data provided, does the SCCS consider Hydroxypropyl p-phenylenediamine and its dihydrochloride salt safe when used in oxidative hair colouring products up to a maximum on-head concentration of 2 %?

In light of the data provided, the SCCS considers that hydroxypropyl p-phenylenediamine and its dihydrochloride salt are safe when used in oxidative hair colouring products up to a maximum on-head concentration of 2%.

2. Does the SCCS have any further scientific concerns with regard to the use of Hydroxypropyl p-phenylenediamine and its dihydrochloride salt in cosmetic products?

A mild to moderate eye irritation potential of the test item cannot be excluded. Hydroxypropyl p-phenylenediamine and its dihydrochloride salt is a moderate skin sensitiser based on animal data.

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