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European Commission to Ban 31 CMR Substances in Cosmetics

from CIRS by

The European Commission is to prohibit the use of 31 carcinogenic, mutagenic or toxic for reproduction (CMR) substances in cosmetic products. The Commission notified WTO of the amendments on November 17, 2022.

The CMRs that are affected include:

  • ammonium bromide;
  • benzophenone;
  • acetamiprid;
  • 2,4,6-tri-tert-butylphenol;
  • dibutyltin di(acetate); and
  • 2-ethylhexanoic acid and its salts, with the exception of those specified in Annex VI to the cosmetic products Regulation.

These substances were added to Annex II of the Regulation (EC) No 1223/2009 and the ban on their use in cosmetics will apply from December 1, 2023.

Previously on May 23, 2022, these 31 substances were added to Annex VI of the Regulation on the classification, labelling and packaging of substances and mixtures (CLP) during the 18th adaptation to technical progress (ATP)

Annex II is amended as follows:

1. Entry 1024 of Annex II is replaced by the following:

Chemical name/INN

CAS number

2-ethylhexanoic acid and its salts with the exception of those specified elsewhere in Annex VI to Regulation (EC) No 1272/2008

149-57-5/-

2. The following entries are added:

Chemical name/INN

CAS number

The Regulatory list in China

Ammonium bromide

12124-97-9

Inventory of Existing Chemical Substances in China (IECSC)

Dibutyltin bis(2-ethylhexanoate)

2781-10-4

IECSC

Dibutyltin di(acetate)

1067-33-0

Tellurium dioxide

7446-07-3

IECSC

Barium diboron tetraoxide

13701-59-2

IECSC

2,2-dimethylpropan-1-ol,tribromo derivative;3-bromo-2,2-bis(bromomethyl)

propan-1-ol

36483-57-5/

1522-92-5

IECSC

2,4,6-tri-tert-butylphenol

732-26-3

IECSC

4,4’-sulphonyldiphenol; bisphenol S

80-09-1

IECSC

Benzophenone

119-61-9

Inventory of Existing Cosmetic Ingredients in China (IECIC 2021)

Quinoclamine(ISO); 2-amino-3-chloro-1,4-naphthoquinone

2797-51-5

Perfluoroheptanoic acid; tridecafluoroheptanoic acid

375-85-9

Methyl N-(isopropoxycarbonyl)-L-valyl- (3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate

283159-90-0

6-[C12-18-alkyl-(branched,unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts

/

6-[(C10-C13)-alkyl-(branched,unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid

2156592-54-8

6-[C12-18-alkyl-(branched,unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid

/

Theophylline;1,3-dimethyl-3,7-dihydro-1Hpurine-2,6-dione

58-55-9

IECIC 2021

1,3,5-triazine-2,4,6-triamine; melamine

108-78-1

IECSC

Fluopicolide (ISO); 2,6-dichloro-N-[3-chloro5-(trifluoromethyl)-2- pyridylmethyl]benzamide

239110-15-7

N-(2-nitrophenyl)phosphoric triamide

874819-71-3

N-(5-chloro-2-isopropylbenzyl)-Ncyclopropyl-3-(difluoromethyl)-5-fluoro-1- methyl-1H-pyrazole-4-carboxamide; isoflucypram

1255734-28-1

Reaction mass of 3-(difluoromethyl)-1-methylN-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9- isopropyl-1,4-methanonaphthalen-5- yl]pyrazole-4-carboxamide and 3- (difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4- carboxamide [>78% syn isomers <15% anti isomers relative content]; isopyrazam

881685-58-1

Margosa, ext. [from the kernels of Azadirachta indica extracted with water and further processed with organic solvents]

84696-25-3

IECIC 2021

Cumene

98-82-8

IECSC

2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3- propanediyl diacrylate; 2,2- bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate;

15625-89-5

IECIC 2021

Pentapotassium 2,2’,2’’,2’’’,2’’’’-(ethane-1,2-diylnitrilo)pentaacetate

7216-95-7

IECSC

Ncarboxymethyliminobis(ethylenenitrilo)tetra(a cetic acid); Pentetic Acid (INCI)

67-43-6

IECIC 2021

Pentasodium(carboxylatomethyl)iminobis(ethylenenitrilo)te traacetate; Pentasodium Pentetate (INCI)

140-01-2

IECIC 2021

Acetamiprid(ISO);(1E)-N-[(6-chloropyridin3-yl)methyl]-N'-cyano-Nmethylethanimidamide;(E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1- methylacetamidine

135410-20-7/ 160430-64-8

IECSC

Pendimethalin(ISO);N-(1-ethylpropyl)-2,6-dinitro-3,4-xylidene

40487-42-1

IECSC

Bentazone (ISO); 3-isopropyl-2,1,3- benzothiadiazine-4-one-2,2-dioxide

25057-89-0

IECSC

Substances including Benzophenone, Theophylline, Melia Azadirachta Seed Extract, Trimethylolpropane Triacrylate, Pentetic Acid, Pentasodium Pentetate are also listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC 2021), if you would like to know more info about these substances or whether your substances are listed in the IECIC, please search our free cosmetic inventory search system – China CosIng 20.

EU,Cosmetic,CMR,Substance,Cosmetic,Prohibition

EU,Cosmetic,CMR,Substance,Cosmetic,Prohibition

EU,Cosmetic,CMR,Substance,Cosmetic,Prohibition

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