May 14, 2022, the proposed Prohibition of Certain Toxic Substances Regulations 2022 were published in Canada Gazette followed by a 75-day public consultation period. The comments can be made before July 28, 2022. These proposed regulations would repeal and replace the Prohibition of Certain Toxic Substances Regulations 2012 on the day the final regulations come into force.

Canada had proposed adding benzophenone and triarylmethanes group to Schedule 1 to the Canadian Environmental Protection Act, 1999 (CEPA). The substances are subject to risk management measures. It was concluded that benzophenone may pose a risk to human health, based upon a comparison of the levels to which Canadians may be exposed to benzophenone when using nail polish, exterior and interior paints as well as stains and the critical endpoints that will affect human health. As a result of the screening assessment, the Government concluded that Malachite Green is harmful to human health at levels of exposure considered in the assessment. Also, Basic Violet 3, Malachite Green, Basic Violet 4, and Basic Blue 7 are concluded to be harmful to the environment.

Introduction The Canadian Environmental Protection Act 1999 (CEPA 1999) is the most important chemical control law in Canada. It is a broad act covering the management of new chemical substances and existing chemicals in Canada. Under CEPA, new substances that not listed on Canada DSL need to be notified before manufacturing or importing while the risk of existing substances are controlled by series of regulatory lists. Besides CEPA, Canada's requirements for workplace chemi

Canadian chemical substance list includes two parts: the Domestic Substance List (DSL), which records more than 23000 substances, and Non-Domestic Substance List (NDSL) which records almost 58000 substances. DSL is used to identify whether a substance is classified as a new substance in Canada. If the substance is not on the DSL, the substance is regarded as a new substance. It shall be notified prior to manufacturing or importing. The NDSL determines the information to be provided. If a new substance is listed on the NDSL, a reduced data for notification may be required.